The settings of PCRE_CASELESS, PCRE_MULTILINE, PCRE_DOTALL, PCRE_UNGREEDY, PCRE_EXTRA, PCRE_EXTENDED and PCRE_DUPNAMES can be changed from within the pattern by a sequence of Perl option letters enclosed between "(?" and ")". The option letters are:
| i | for PCRE_CASELESS | 
| m | for PCRE_MULTILINE | 
| s | for PCRE_DOTALL | 
| x | for PCRE_EXTENDED | 
| U | for PCRE_UNGREEDY | 
| X | for PCRE_EXTRA (no longer supported as of PHP 7.3.0) | 
| J | for PCRE_INFO_JCHANGED | 
For example, (?im) sets case-insensitive (caseless), multiline matching. It is also possible to unset these options by preceding the letter with a hyphen, and a combined setting and unsetting such as (?im-sx), which sets PCRE_CASELESS and PCRE_MULTILINE while unsetting PCRE_DOTALL and PCRE_EXTENDED, is also permitted. If a letter appears both before and after the hyphen, the option is unset.
   When an option change occurs at top level (that is, not inside
   subpattern parentheses), the change applies to the remainder of the
   pattern that follows. So /ab(?i)c/ matches only "abc"
   and "abC".
  
   If an option change occurs inside a subpattern,  the  effect
   is  different.  This is a change of behaviour in Perl 5.005.
   An option change inside a subpattern affects only that  part
   of the subpattern that follows it, so
   (a(?i)b)c
   matches  abc  and  aBc  and  no  other   strings   (assuming PCRE_CASELESS is not
   used). By this means, options can be made to have different settings in
   different parts of the pattern. Any changes made in one alternative do
   carry on into subsequent branches within the same subpattern. For
   example,
   (a(?i)b|c)
   matches "ab", "aB", "c", and "C", even though when  matching
   "C" the first branch is abandoned before the option setting.
   This is because the effects of  option  settings  happen  at
   compile  time. There would be some very weird behaviour otherwise.
  
The PCRE-specific options PCRE_UNGREEDY and PCRE_EXTRA can be changed in the same way as the Perl-compatible options by using the characters U and X respectively. The (?X) flag setting is special in that it must always occur earlier in the pattern than any of the additional features it turns on, even when it is at top level. It is best put at the start.